hrp0084p2-186 | Adrenals | ESPE2015

Testicular Adrenal Cell Rest Tumours are not Associated with 21 Hydroxylase Mutations or Therapy Compliance in Boys with Classic form of CAH

Kocova Mirjana , Janevska Vesna , Anastasovska Violeta , Sukarova-Angelovska Elena

Background: Testicular adrenal cell rest tumours (TART) are common in adult males treated for congenital adrenal hyperplasia (CAH) and contribute to reduced fertility. Their prevalence varies between 6-50%, and the incidence raises during adolescence.Aim: To explore the appearance of TART in a group of 25 male children in the age group 3-18 years who were treated for CAH.Methods: Compliance to the treatment was assessed through 17O...

hrp0092p3-248 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Difficulties in Diagnosing Variable Disorders of Sexual Development

Sukarova-Angelovska Elena , Krstevska-Konstantinova Marina , Alulovska Natasa , Ilieva Gordana , Anastasovska Violeta

Introduction: Disorders of sexual development (DSD) include etiologically heterogeneous group of patients that have disorders of genital development. Consensus guidelines that are currently used, divide all DSD in three main groups - sex chromosomal abnormalities, XX or XY DSD, all divided in subgroups in dependence of genetics and hormonal tests. The phenotypic spectrum of external genitalia, gonads and development of Wolfian and Mulerian duct derivatives var...